Ask the Experts: Can You Be Allergic to Sperm?

Question:

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Can someone really be allergic to their partner’s sperm?

Answer:

The idea of being allergic to sperm is more common than you might think, but it often means different things based on the tests done. True sperm incompatibility is quite rare. Some women have undergone blood tests looking for anti-sperm antibodies, but a positive result doesn’t always indicate a real compatibility issue or infertility. In fact, this test is no longer routinely recommended for infertility evaluations.

A more relevant concern might arise from the male partner producing antibodies against his own sperm, which can happen in cases of testicular injury or after certain surgeries. Men who have had a vasectomy reversal are also at risk, especially if a significant amount of time has passed since the vasectomy. The sperm consists of three parts: the head, midpiece, and tail. If antibodies target the midpiece or tail, it’s usually not a problem. However, if they target the head, this can hinder the sperm from properly fusing with the egg, which is crucial for fertilization.

In such cases, the solution typically involves in vitro fertilization (IVF) where a procedure called ICSI (intracytoplasmic sperm injection) is used. This technique allows an embryologist to inject the sperm directly into the egg, improving the chances of successful fertilization. If you suspect a sperm compatibility issue, be sure to discuss the appropriate testing with your fertility doctor. The anti-sperm antibody test should be conducted directly on the sperm by a specialized lab, such as an IVF or Andrology lab.

If you think you might be at risk for developing antibodies against your own sperm, chat with your fertility physician about it. And if you’re curious about family planning and pregnancy, check out our post on crafting baby announcements for some creative ideas or visit Healthline for more pregnancy insights.

Summary:

Allergies to sperm can be misunderstood; true incompatibility is rare. Women may test for anti-sperm antibodies, but results might not indicate real issues. Men can develop antibodies against their sperm, especially after certain medical situations. IVF and ICSI can help in cases of sperm issues. Always consult your fertility doctor for the right tests and options.