Hey there! If you’re exploring the world of genetic testing, specifically Preimplantation Genetic Testing for Monogenic Disease (PGT-M), you’re in the right place. This testing isn’t for everyone, but for those who may be carriers of certain genetic disorders, it can be a game-changer. It significantly boosts the likelihood of having children without those specific genetic conditions.
Before diving into PGT-M, a chat with a genetic counselor is essential. Setting everything up for PGT-M can take some time—think weeks to months—since it’s customized for each family’s unique situation. To undergo PGT-M, you’ll need to go through IVF (in vitro fertilization) to create embryos for testing. IVF involves taking fertility medications to help the ovaries produce multiple eggs. These eggs are then harvested and fertilized with sperm in a lab, leading to the formation of early embryos, or blastocysts.
Ideally, when going through IVF, couples generate several embryos. A small number of cells will be biopsied from each embryo on days 5 to 7 and sent to a specialized PGT lab for analysis. Don’t worry! Research and our own experiences suggest that this biopsy doesn’t harm the embryos. After testing, embryos found to be free of genetic diseases can be transferred into the uterus. Since the testing takes about a week, the embryos will need to be frozen until the results are available. Once you have those results, a frozen embryo transfer can be arranged.
When to Consider PGT-M
So, when should you consider PGT-M? It’s recommended for those who are at risk of passing on a genetic disorder—maybe you’ve had a child with a genetic issue in the past, or a family member carries a mutation. At our center, we provide extensive carrier screening for over 200 conditions to identify couples who might benefit from PGT-M. If a genetic variant is found, the next step is working with a genetic counselor to see if PGT-M is feasible for your situation.
It’s important to note that the accuracy of PGT-M ranges from 95% to 99%. To further confirm these results, additional genetic testing during pregnancy is recommended. This can include procedures like amniocentesis or CVS (chorionic villus sampling). Amniocentesis is typically performed between 16-20 weeks of pregnancy, where a small sample of amniotic fluid is taken for testing. On the other hand, CVS can be done earlier, between 10-12 weeks, where a tiny sample of the placenta is collected.
Next Steps
If you’re considering PGT-M, it’s vital to reach out to a genetic counselor to discuss your options. For a detailed look at nutrition’s role in boosting fertility, check out this helpful blog post. And if you’re looking for an insemination kit, CryoBaby has some great options.
In summary, PGT-M is a powerful tool for couples at risk of passing on genetic diseases. It requires careful planning and coordination with healthcare professionals, but the potential benefits for your future family can be immense.